![]() ![]() Using a commercial DNA isolation kit, circulating cell-free DNA (ccfDNA) was extracted from the maternal plasma samples. Maternal plasma was separated from whole blood via centrifugation. Three to four milliliters (mL) of maternal blood were drawn from each participant via venipuncture at three gestational ages (i.e., 6, 7, and 8 -10 weeks’ gestation). After excluding participants that reported miscarriage during the study, reported twin/triplet pregnancy, or miscalculated gestational age at the time of the initialsample collection, 115 individuals completed the trial in its entirety. Method: Between May and September 2021, 156 pregnant women were recruited from 12 clinics in the United States. The SneakPeek assay was further optimized to enable fetal sex identification at earlier gestations and its performance characteristics were determined at 6-weeks’ gestation. To our knowledge, no prior study has shown fetal sex identification from maternal plasma earlier than seven weeks of gestation with high accuracy. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Ĭlinics Mother Child Health, Vol.19 Iss.4 No:1000419 ABSTRACTīackground: The SneakPeek® Early Gender Test was previously shown to be 99.9% accurate in determining fetal sex as early as seven weeks of gestation. CMCH-22-17127 (R) Published: 0, DOI: 10.35248/2090-7214.22.19.419Ĭitation: Szucs HD, Asprer L, Abunadi N, Milot H, Cacia S, Jacob C (2022)SneakPeek Early Gender Test: The Earliest and Most Accurate Method for Fetal Sex Determination at 6-Weeks Gestation. CMCH-22-17127 Editor assigned: 1, PreQC No. Gateway Genomics, San Diego, California, USAĬorrespondence to: Henriett Diana Szucs, Gateway Genomics, San Diego, California, US, E-mail: 0, Manuscript No. This blinded study showed that SneakPeek Early Gender Test is highly accurate for fetal sex determination in early pregnancy.Henriett Diana Szucs*, Lia Asprer, Nora Abunadi, Haley Milot, Sarah Cacia, Chris Jacob SneakPeek accuracy, sensitivity and specificity were each 100% for fetal sex identification. Fetal sex for all samples was unknown prior to genetic testing and was confirmed via sonographic evaluation at the conclusion of the study. ![]() Assay precision data showed minimal variation and high reproducibility of results. SneakPeek correctly identified fetal sex in all samples. Y-chromosome DNA was detected in all samples from women carrying a male fetus. Sixty maternal plasma samples were tested twice, on different days, to assess the precision of SneakPeek.Ĭell-free DNA was detected in all maternal blood samples. An autosomal control gene was used to measure total cell-free DNA (maternal and fetal cfDNA). Circulating cell-free DNA was isolated from a micro-volume of maternal plasma and real-time quantitative PCR was performed to detect fetal DNA using a multi-copy sequence on the Y chromosome. A multicenter-blinded study was conducted at four ultrasound clinics with maternal blood samples collected from pregnant women between 9 and 35 weeks of gestation. The purpose of this study was to assess the clinical performance of SneakPeek® Early Gender Test (Gateway Genomics) for noninvasive prenatal testing (NIPT) of fetal sex. Multicenter blinded study conducted at four ultrasound clinics in 2015 SneakPeek Clinical Accuracy Studies Multicenter Blinded Study of SneakPeek® Early Gender Test If it is detected then the baby’s gender is male and if it is not detected then the baby’s gender is female. Our PCR technology has the ability to detect the presence or absence of male Y chromosome in the blood sample provided starting at 9 weeks into pregnancy. SneakPeek utilizes the natural process of shared fetal DNA circulating inside the mother’s bloodstream. ![]() The laboratories offer the fastest turnaround times in the industry, with a choice of receiving your result the same day the sample reaches the SneakPeek Lab. The full service includes an on-site phlebotomist that draws a blood sample in the comfort of our facility, and then returns the sample to SneakPeek Labs for processing. The genetic test gives you the first step to connect with your baby before you are able to see the exciting clear images from your ultrasound scans. SneakPeek Clinical is an early gender DNA detection test offered to women starting at 9 weeks into pregnancy. ![]()
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